Pirarubicin synthesis
Webb14 dec. 2024 · Overview : pirarubicin (THP), also known as pirarubicin, is an anthracycline antibiotic. The mechanism of the anticancer effect of pirarubicin is that it rapidly … WebbSynthesis of Enzymatically Cleavable Pirarubicin Derivative—N 3-pent-GFLG-Pir N 3 -pent-GFLG-OH was prepared on 2-chlorotrityl chloride resin as described earlier [ 23 ]. Pirarubicin was attached to the peptide carboxylic group using DIC/NHS activation similarly as described in our previous work [ 23 ], except that the condensation of the peptide with …
Pirarubicin synthesis
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Webb22 dec. 2014 · Pirarubicin (4′-O-tetrahydropyranyldoxorubicin, THP), a semisynthetic derivative of doxorubicin, 1 is one of the anthracycline antitumor drugs used clinically for … WebbSynthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin Kenji Tsukigawa, Shuhei Imoto, Keishi Yamasaki, Koji ... In a previous study, …
WebbThe invention discloses a steady freeze drying medicament which mainly contains pirarubicin, oiliness carrier, surface activator, cryodesiccation sustaining agent, and intralipid with an even grain diameter less than 1000nm is freezed and dried. The redissolved grain size is less than 2000nm, and the pH lever of the fluid is between 4 and … WebbPirarubicin is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as an antineoplastic …
WebbPirarubicin is a new kind of anthracene nucleus broad-spectrum antitumor antibiotic. This compound was rapidly incorporated into tumor cells, inhibiting DNA polymerase alpha, … Webb25 dec. 1996 · Different modes of preparation were used and compared, ... The second method consisted of spreading mixtures of POPC/pirarubicin (pirarubicin being now …
WebbPirarubicin. CAT No: SZ-P129001. CAS No: 72496-41-4. Mol.F. : C32H37NO12. Mol.Wt. : 627.6. Inv. Status: Custom Synthesis.
WebbThe application discloses a method for separating and purifying pirarubicin, which at least comprises the following steps: step 1, obtaining a solution to be treated of a sample containing pirarubicin; step 2, separating and purifying the solution to be treated by adopting chromatography to obtain a pure pirarubicin product; the filler adopted in the … mike tyson punch out piston honda codeWebbPirarubicin (INN) is an anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with … mike tyson punch out online google sitesWebbMolar mass. 435.455 g·mol −1. Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N. verify ( what is. Y N. ?) Infobox references. Exatecan is a drug which is a structural analog of camptothecin with antineoplastic activity. mike tyson punch out rory hollowayWebb1 juni 2015 · Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less … mike tyson punch out posterWebbPirarubicin is an anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with … new world glowing gnufish locationWebbThe invention discloses a pirarubicin freeze-dried preparation. The preparation is composed of the following components with the contents: 8 to 12g of pirarubicin or pirarubicin hydrochloride, 50 to 75g of hydrogenated soybean lecithin, 28 to 42g of cholesterol, 3 to 5g of PEG2000-1, 2-dipalmitoyl-glycero-3-phosphoethanolamine, 1.2 to … new world glow worm baitWebbPirarubicin is a new kind of anthracene nucleus broad-spectrum antitumor antibiotic. This compound was rapidly incorporated into tumor cells, inhibiting DNA polymerase alpha, … mike tyson punch out passenger