WebApr 12, 2024 · Interestingly, in an AD mouse model, neuronal ApoE CT migrates to amyloid plaques in the subiculum from other regions and alleviates the plaque burden. Together, our data reveal a hidden role of ApoE as a γ-secretase inhibitor with substrate specificity and suggest that this precision γ-inhibition by ApoE may protect against the risk of sAD. WebJul 4, 2024 · Peroxynitrite is a highly toxic, reactive molecule, which can cause cell damage (by lipid peroxidation and DNA fragmentation), tissue damage depletion of plasmatic …
Neurodegenerative disorders: the role of peroxynitrite
WebPeroxynitrite is a strong oxidizing and nitrating agent which can react with all classes of biomolecules. In the CNS it can be generated by microglial cells activated by pro … WebMay 6, 2024 · Type 1 diabetes (T1D) is an autoimmune disease caused by selective destruction of pancreatic β-cells. During islet inflammation ... These data suggest that the cytoplasmic thioredoxin reductase is necessary for β-cells to detoxify peroxynitrite. Fig. 7.Inhibition or knockdown of thioredoxin reductase sensitizes INS 832/13 cells and rat … black sequin dress high resolution
Nitric oxide and peroxynitrite in health and disease
WebJun 20, 2024 · Nitrite promotes the inhibition of Streptococcus mutans growth and biofilm formation by Streptococcus parasanguinis. ( A) Plate inhibition assay of Sp ( S. parasanguinis) and Smu ( S. mutans) on Todd-Hewitt agar ±2mM nitrite. Sp was plated 24 h prior to spotting Smu. WebApr 15, 1997 · Increasing evidence suggests that oxidative damage to proteins and other macromolecules is a salient feature of the pathology of Alzheimer’s disease. Establishing the source of oxidants is key to understanding what role they play in the pathogenesis of Alzheimer’s disease, and one way to examine this issue is to determine which oxidants … WebPeroxynitrite (ONOO −) the highly reactive coupling product of nitric oxide and superoxide, has been implicated in the pathogenesis of an increasing number of (inflammatory) diseases.At present, however, selective peroxynitrite antagonizing agents with therapeutic potential are not available. Therefore, the NADPH-oxidase inhibitor apocynin (4-hydroxy-3 … garry strachan