WebFeb 1, 2024 · Dedicator of cytokinesis 2 (DOCK2) deficiency protects mice from chronic high-fat and high-fructose (HFHF) diet–induced lung inflammation/injury. A: Body weight of DOCK2 knockout (DOCK2 −/− ) mice fed a normal chow diet or an HFHF diet for 20 weeks. WebMar 18, 2015 · Dedicator of cytokinesis 2 (DOCK2) is a novel protein factor regulating SMC phenotypic modulation and vascular remodeling. Deletion of DOCK2 blocks injury …
American Journal of Respiratory Cell and Molecular Biology
WebApr 12, 2024 · DOCK2 (dedicator of cytokinesis 2) expression was induced in human pleural fibrosis. ( A ) Hematoxylin and eosin staining in human normal and pleuritis lung suggested increased fibrosis in the visceral pleura of a patient with nonspecific pleuritis versus that in a normal control patient. WebMar 18, 2015 · Dedicator of cytokinesis 2 (DOCK2 [DK2]) deficiency attenuated injury-induced neointima formation and smooth muscle cell … lego ghostbusters light kit
Dedicator of cytokinesis protein 2 couples with lymphoid …
WebApr 11, 2024 · In this study, we explored the regulation between circular forms of dedicator of cytokinesis 1 (circDOCK1) (hsa_circ_0007142) and miR-128-3p, and its implication on the pathogenesis of breast cancer modulated by never in mitosis (NIMA) related kinase 2 (NEK2). We revealed an increase in circDOCK1 and NEK2 expression, and a decrease … WebDedicator of cytokinesis 2 (DOCK2) is a Rac activator predominantly expressed in hematopoietic cells. Although DOCK2 regulates migration and activation of leukocytes, its role in MCs remains unknown. Objective: We aimed to elucidate whether—and if so, how—DOCK2 is involved in MRGPRX2/B2-mediated MC degranulation and anaphylaxis. WebDock11 (Dedicator of cytokinesis), also known as Zizimin2, is a large (~240 kDa) protein involved in intracellular signalling networks. [5] [6] It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors (GEFs) which function as activators of small G proteins. Dock11 activates the small G protein Cdc42 . lego ghostbusters all bosses